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Huge Online Sale - Save Up to 20% on all Medicine Today! Opana ER is an extended-release oral form of oxymorphone hydrochloride, an opioid pain medication approved for treating moderate to severe acute or chronic pain. Its active ingredient, oxymorphone, is a synthetic opioid related to morphine, codeine, and heroin. Each tablet provides a precise medicine dose released over 12 hours, allowing patients to receive their medication at all times without interruptions