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Methadone is used to treat severe pain and narcotic addiction. Methadone is an opioid, a class of drugs that affects the central nervous system (CNS) and has this central effect on the brain. The exact mechanism by which methadone provides pain relief depends on the type of pain condition being treated, but it may include a mixture of different mechanisms that include blocking opioid receptors, distorting neuronal communication and/or reducing levels of norepinephrine responsible for painful sensations in the brain.